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For more severe deficiencies due to malabsorption or other underlying conditions, injections of vitamin B12 may be necessary

Vitamin B12 Cyanocobalamin Injection by American Regent is a sterile solution used to treat vitamin B12 deficiency and prevent associated conditions such as pernicious anemia and neurological disorders

CD73/adenosine pathway involvement in the interaction of non-small cell lung cancer stem cells and bone cells in the pre-metastatic niche

Although there are some secondary biomarkers such as the measurement of certain enzyme activities in the leukocytes or the excretion of 3-hydroxy-3-methylbutyric acid in the urine, these are ambiguous indications and only a few doctors are familiar with the corresponding tests (8, 9)